| Catalogue number | C101234 |
| Chemical name | Catalpalactone |
| CAS Number | 1585-68-8 |
| Synonyms | 3-(2,2-dimethyl-6-oxo-3H-pyran-5-yl)-3H-isobenzofuran-1-one |
| Molecular Weight | C15H14O4 |
| Formula | 258.3 |
| Purity | 98% |
| Physical Description | Powder |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | The effects of catalpalactone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells were investigated. Catalpalactone at 5-30μM decreased intracellular dopamine content with the IC(50) value of 22.1μM. Catalpalactone at 5-20μM, but not 30μM, did not alter cell viability. Catalpalactone at 20μM inhibited tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities. Catalpalactone also decreased cyclic AMP levels and inhibited TH phosphorylation. In addition, catalpalactone at 20μM reduced the increases in dopamine levels induced by L-DOPA (20-50μM). Catalpalactone (5-30μM) associated with L-DOPA (50-100μM) enhanced L-DOPA-induced cytotoxicity at 48h, which was prevented by N-acetyl-l-cysteine. These results suggest that catalpalactone inhibited dopamine biosynthesis by reducing TH and AADC activities and enhanced L-DOPA-induced cytotoxiciy in PC12 cells. |
| References | 1. Tetrahedron Letters, 1982, 23(43), 4457-4460. 2. Environ Toxicol Pharmacol., 2008, 26(1), 86-91. 3. Chemical & Pharmaceutical Bulletin, 1967, 15(6), 786-792. |
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After Receiving
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