CDDO Methyl Ester

Catalogue number C213964
Chemical nameCDDO Methyl Ester
CAS Number218600-53-4
Synonyms2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid Methyl Ester; Bardoxolone Methyl; CDDO-Me; Methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate; NSC 713200; RTA 402;
Molecular WeightC32H43NO4
Formula505.69
Purity98%
Physical DescriptionWhite to Tan Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsCDDO Methyl Ester is a synthetic triterpenoid that inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells. CDDO Methyl Ester is a novel therapeutic agent in the treatment of acute myeloid leukemia and in the treatment of pancreatic cancer as well as other forms of cancer.
ReferencesShishodia, S. et al.: Clin. Cancer Res., 12, 1828 (2006); Konopleva, M. et al.: Leukemia, 19, 1350 (2005); Deeb, D. et al.: Cancers, 2, 1779 (2010); Gao, X. et al.: J. Exp. Therap. Oncol., 9, 119 (2011);
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CDDO Methyl Ester
Price(USD)
SizePrice(USD)Discount
5mg$50.0010% OFF
25mg$95.0010% OFF
100mg$360.0010% OFF
10mg$70.0010% OFF
50mg$185.0010% OFF
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