| Catalogue number |
C108464 |
| Chemical name | Byakangelicin |
| CAS Number | 19573-01-4 |
| Synonyms | 9-(2,3-dihydroxy-3-methylbutoxy)-4-methoxy-7-furo[3,2-g][1]benzopyranone |
| Molecular Weight | C17H18O7 |
| Formula | 334.3 |
| Purity | 98% |
| Physical Description | White cryst. |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Antineoplastic agent.
Inhibitory effect of byakangelicin on and presence of sulphydryl group in pregnant mare's serum gonadotropin.
In human primary hepatocytes, byakangelicin markedly induced the expression of CYP3A4 both at the mRNA level (approximately five fold) and the protein level (approximately three fold) but did not affect expression of human pregnane X receptor (hPXR). In reporter assays, byakangelicin activated CYP3A4 promoter in a concentration-dependent manner (EC50= 5 µM), and this activation was enhanced by co-transfection with hPXR. Further reporter assays demonstrated that the eNR4 binding element in the CYP3A4 promoter was required for the transcriptional activation of CYP3A4 by byakangelicin. Byakangelicin induced expression and activity of CYP3A4 in human hepatocytes. This induction was achieved by the transactivation of PXR and not by increased expression of PXR. Therefore, byakangelicin is likely to increase the expression of all PXR target genes (such as MDR1) and induce a wide range of drug-drug interactions.
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| References | 1. Planta Med., 1969, 17, 116.
2. Journal of Chromatography B: Biomedical Sciences and Applications, 2001, 753(2), 309-314.
3. British Journal of Pharmacology, 2011, 162(2), 441-451.
4. Indian Journal of Experimental Biology, 1968, 6(4), 212-215.
5. Journal of Ethnopharmacology, 2004, 93(2-3), 243-246.
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| Size | Price(USD) | Discount |
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| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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