| Catalogue number |
C107931 |
| Chemical name | Buddleoside |
| CAS Number | 480-36-4 |
| Synonyms | 5-hydroxy-2-(4-methoxyphenyl)-7-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-2-oxanyl]oxymethyl]-2-oxanyl]oxy]-1-benzopyran-4-one |
| Molecular Weight | C28H32O14 |
| Formula | 592.6 |
| Purity | 98% |
| Physical Description | Yellow powder |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Linarin (acacetin-7-O-β-d-rutinoside) showed selective dose dependent inhibitory effect on acetylcholinesterase.
PC12 cells were cultured and exposed to 30 mu M A beta(25-35) in the absence or presence of linarin (0.1, 1.0 and 10 mu M). In addition, the potential contribution of the PI3K/Akt neuroprotective pathway in linarin-mediated protection against A beta(25-35)-induced neurotoxicity was also investigated. The results showed that linarin dose-dependently increased cell viability and reduced the number of apoptotic cells as measured by MTT assay, Annexin-V/PI staining, JC-1 staining and caspase-3 activity assay. Linarin could also inhibit acetylcholinesterase activity induced by A beta(25-35) in PC12 cells. Further study revealed that linarin induced the phosphorylation of Akt dose-dependently. Treatment of PC12 cells with the PI3K inhibitor LY294002 attenuated the protective effects of linarin. Furthermore, linarin also stimulated phosphorylation of glycogen synthase kinase-3 beta (GSK-3 beta), a downstream target of PI3K/Akt. Moreover, the expression of the anti-apoptotic protein Bcl-2 was also increased by linarin treatment. These results suggest that linarin prevents A beta(25-35)-induced neurotoxicity through the activation of PI3K/Akt, which subsequently inhibits GSK-3b and up-regulates Bcl-2. These findings raise the possibility that linarin may be a potent therapeutic compound against Alzheimer's disease acting through both acetylcholinesterase inhibition and neuroprotection.
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| References | 1. Z. Naturforsch., 2005, 60b, 211-214.
2. Fitoterapia, 2006, 77(6), 429-434.
3. BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19(13), 4021.
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The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
| Size | Price(USD) | Discount |
| 5mg | Inquiry | N/A |
| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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