Buddlejasaponin IV

Catalogue number C108450
Chemical nameBuddlejasaponin IV
CAS Number139523-30-1
Synonyms(3beta,13alpha,16beta,17alpha)-16,23-dihydroxy-13,28-epoxyolean-11-en-3-yl beta-D-glucopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->3)]-6-deoxy-beta-D-galactopyranoside
Molecular WeightC48H78O18
Formula943.1
Purity98%
Physical DescriptionWhite powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsBuddlejassaponin IV has an antihepatotoxic effect.
Buddlejasaponin IV significantly inhibited nitric oxide (NO) production, and it also significantly decreased prostaglandin E2 (PGE2) and tumor necrosis factor-a (TNF-a) release in the lipopolysaccharide (LPS)-activated macrophage Raw 264.7 cells.
Buddlejasaponin IV was found to significantly inhibit hypercholesterolemia and hyperlipidemia by extrinsic and intrinsic inducers. In particular, Buddlejasaponin IV reduced the blood thiobarbituric acid reactive substance (TBARS) and hydroxy radical levels, and increased superoxide dismutase activity in high cholesterol diet-induced rats, thus suggesting that Buddlejasaponin IV reduces oxidative stress caused by a high cholesterol diet. Moreover, these effects of Buddlejasaponin IV were comparable to probucol, which was used as a positive control.
References1. Chem. Pharm. Bull., 1991, 39, 2764-2766.
2. Planta Med., 1993, 60, 163-167.
3. Biol. Pharm. Bull., 2005, 28(9), 1668-1671.
4. British Journal of Pharmacology, 2006, 148(2), 216-225.
5. Journal of Ethnopharmacology, 2007, 112(2), 255-261.
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Buddlejasaponin IV
Price(USD)
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