| Catalogue number | C209292 |
| Chemical name | Bizelesin |
| CAS Number | 129655-21-6 |
| Synonyms | N,N’-Bis[2-[[(1S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo[1,2-b:4,3-b’]dipyrrol-3(2H)-yl]carbonyl]-1H-indol-5-yl]urea; (8S,8’S)-6,6’-[Carbonylbis(imino-1H- indole-5,2-diylcarbonyl)]bis[8-(chloromethyl)-3,6,7,8-tetrahyd |
| Molecular Weight | C43H36Cl2N8O5 |
| Formula | 815.7 |
| Purity | 98% |
| Physical Description | Powder |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | As members of the cyclopropylpyrroloindole family, Adozelesin and Bizelesin cause genomic DNA lesions by alkylating DNA. Adozelesin induces single-strand DNA lesions, whereas Bizelesin induces both single-strand lesions and double-strand DNA cross-links. Thus, despite similar abilities to alkylate DNA, the chemotherapeutic agents Adozelesin and Bizelesin caused a decrease in HCT116 tumor cell proliferation by different pathways (i.e., Adozelesin induced apoptosis, and Bizelesin induced senescence). |
| References | Lee, C., et al.: Cancer Res., 51, 6586 (1991), McHugh, M., et al.: Biochemistry, 38, 11508 (1999), Liu, J., et al.: J. Biol. Chem., 275, 1391 (2000), |
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After Receiving
The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Price(USD)
| Size | Price(USD) | Discount |
| 10mg | $9750.00 | 10% OFF |
| 100mg | $32500.00 | 10% OFF |
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To place an order, please provide the following information.
1) Your name and telephone number
2) Purchase order number
3) Product number, package size, description, and quantity
4) Shipping and billing addresses
Sent to your order to our email: info@coompo.com
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