Bisdemethoxycurcumin

Catalogue number C108642
Chemical nameBisdemethoxycurcumin
CAS Number33171-05-0
Synonyms(E,E)-1,7-Bis(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione; Bisdesmethoxycurcumin, Didemethoxycurcumin; Diferuloylmethane; Curcuma yellow; Natural Yellow 3.
Molecular WeightC19H16O4
Formula308.3
Purity98%
Physical DescriptionYellow powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Antiedemic, anti-inflammatory agent. Bile stimulant showing hepatoprotective props. Possesses bactericidal and fungicidal props. Antitumour agent functioning through apoptosis. Nutriceutical. Shows antioxidant activity.


Bisdemethoxycurcumin (BDMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. BDMC shares similar anti-inflammatory properties with demethoxycurcumin. It inhibits LPS-induced nitric oxide (NO) production and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. BDMC also displays unique properties in that it enhances Abeta clearance by upregulating expression MGAT3 and TLR genes. BDMC potently inhibits AKR1B10.

References1. Carcinogenesis, 1995, 16(10), 2493-2497.
2. Food Research International, 2005, 38(8-9), 1039-1044.
3. J. Agric. Food Chem., 2008, 56(20), 9328-9336.
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Bisdemethoxycurcumin
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