Bardoxolone

Catalogue number C205470
Chemical nameBardoxolone
CAS Number218600-44-3
SynonymsCDDO; RTA 401; 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid;
Molecular WeightC31H41O4
Formula491.66
Purity98%
Physical DescriptionLight Brown Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsBardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPARγ. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events.
ReferencesShepler, B., et al.: Clinical. Therap., 34, 1237 (2012); Speranza, G., et al.: Cancer. Chemo. Pharmacol., 69, 431 (2012); Sporn, M.B., et al.: J. Natural. Prod., 74, 537 (2011);
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Bardoxolone
Price(USD)
SizePrice(USD)Discount
1mg$50.0010% OFF
10mg$350.0010% OFF
50mg$900.0010% OFF
5mg$195.0010% OFF
25mg$575.0010% OFF
100mg$1120.0010% OFF
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