Coompo Research Chemicals

Bakuchiol against oxidative damages to lipids and proteins has been investigated and rationalized based on the scavenging activity of Bakuchiol against various oxidizing radicals. the importance of the terpenoid moiety of bakuchiol in controlling its antioxidant action via radical scavenging.

The antimicrobial activities of bakuchiol against some oral microorganisms were evaluated in vitro. The cell growth of Streptococcus mutans was inhibited in a bakuchiol concentration-dependent manner, and growth of S. mutans was completely prevented by 20 μg of bakuchiol per ml. The bactericidal effect of bakuchiol on S. mutans was dependent on temperature and stable under the following conditions: sucrose, 0 to 10% (wt/vol); pH, 3.0 to 7.0; organic acids (3% [wt/vol] citric and malic acids). Bakuchiol showed bactericidal effects against all bacteria. Furthermore, bakuchiol was also effective against adherent cells of S. mutans in water-insoluble glucan in the presence of sucrose and inhibited the reduction of pH in the broth. Thus, bakuchiol would be a useful compound for development of antibacterial agents against oral pathogens and has great potential for use in food additives and mouthwash for preventing and treating dental caries.

Bakuchiol is widely used to treat a variety of diseases and it possesses anti-tumor, anti-bacterial, cytotoxic and anti-helmenthic properties. The cytotoxicity of bakuchiol is mainly due to its DNA polymerase1 inhibiting activity. 125I, an auger electron emitter, is an effective radiotherapeutic agent when targeted close to DNA.