BAY 87-2243

Catalogue number C205494
Chemical nameBAY 87-2243
CAS Number1227158-85-1
Synonyms1-Cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]-piperazine
Molecular WeightC26H26F3N7O2
Formula525.53
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsBAY 87-2243 is a highly potent and selective inhibitor of hypoxia-induced gene activation. It is found to inhibit HIF-1α and HIF-2α protein accumulation under hypoxic conditions in non-small cell lung cancer cell line H460. It inhibits mitochondrial complex I activity and therefore may be used in antitumor treatment to overcome chemo- and radiotherapy- resistance of hypoxic tumors.
ReferencesEllinghaus, P., et al.: Cancer Med., 2, 611 (2013)
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BAY 87-2243
Price(USD)
SizePrice(USD)Discount
25mg$140.0010% OFF
100mg$500.0010% OFF
50mg$260.0010% OFF
250mg$1120.0010% OFF
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