Ataciguat

Catalogue number C209722
Chemical nameAtaciguat
CAS Number254877-67-3
Synonyms5-Chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide; HMR 1766;
Molecular WeightC21H18Cl2N3O6S3
Formula576.49
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsAtaciguat, formerly referred to as HMR-1766, a novel anthranilic acid derivative, belongs to a new structural class of sGC activators capable of activating the oxidized form of sGC. Ataciguat has been shown to improve endothelial function and to reduce platelet activation in exptl. diabetes. Chronic regular treatment with sGC activators such as ataciguat could therefore eventually constitute an effective therapy targeting deficient NO/cGMP signaling in hypertension, peripheral and coronary artery disease, heart failure, thrombosis and erectile dysfunction.
ReferencesButt, E., et al.: J. Biol. Chem., 269, 14509 (1994), De Angelis, L., et al.: Diabetologia, 44, 1155 (2001), Schafer, A., et al.: Biochem. Pharmacol., 65, 397 (2003), Massberg, S., et al.: Blood, 103, 136 (2004), Stasch, J., et al.: J. Clin. Invest., 116, 2552 (2006),
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Ataciguat
Price(USD)
SizePrice(USD)Discount
1mg$65.0010% OFF
10mg$475.0010% OFF
5mg$275.0010% OFF
25mg$950.0010% OFF
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