Aconitine

Catalogue number C204207
Chemical nameAconitine
CAS Number302-27-2
Synonyms(1α,3α,6α,14α,15α,16β)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-Acetate 14-Benzoate;
Molecular WeightC34H47NO11
Formula645.74
Purity98%
Physical DescriptionOff-White Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsNeurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization. Used in producing heart arrhythmia in experimental animals.
ReferencesDerbre, S., et al.: Anal. Bioanal. Chem., 398, 1747 (2010), Li, M., et al.: J. Pharm. Biomed. Anal., 53, 1063 (2010),
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Aconitine
Price(USD)
SizePrice(USD)Discount
5mg$50.0010% OFF
25mg$60.0010% OFF
100mg$120.0010% OFF
10mg$55.0010% OFF
50mg$80.0010% OFF
250mg$235.0010% OFF
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