6-Amino-4-(4-phenoxyphenylethylamino)quinazoline

Catalogue number C202851
Chemical name6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
CAS Number545380-34-5
SynonymsN4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine; QNZ;
Molecular WeightC22H20N4O
Formula356.42
Purity98%
Physical DescriptionOff-White to Brownish-Yellow S
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsQNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-α production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1mg/Kg). A useful tool to explore the role of NFkB in cellular signaling pathways.
ReferencesTobe, M., et al.: Bioorg. Med. Chem., 11, 3869 (2003), Choi, S., et al.: J. Biol. Chem., 281, 12722 (2006)
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6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
Price(USD)
SizePrice(USD)Discount
500µ$50.0010% OFF
g10% OFF
2mg$65.0010% OFF
10mg$140.0010% OFF
1mg$55.0010% OFF
5mg$85.0010% OFF
25mg$360.0010% OFF
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