4-Hydroxycinnamamide

Catalogue number C101047
Chemical name4-Hydroxycinnamamide
CAS Number194940-15-3
Synonyms3-(4-hydroxyphenyl)-2-propenamide
Molecular WeightC9H9NO2
Formula163.2
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsInhibition by seven synthetic 4-hydroxycinnamamide derivatives, ST 271, ST 280, ST 458, ST 494, ST 633, ST 638, and ST 642, of tyrosine-specific protein kinases (tyrosine kinase) of oncogene or proto-oncogene products (p130gag-v-fps, p70gag-actin-v-fgr, pp60v-src, pp60c-src) and epidermal growth factor (EGF) receptor kinase were investigated. ST 638 (alpha-cyano-3-ethoxy-4-hydroxy-5-phenylthiomethylcinnamamide) strongly inhibited more of the tyrosine kinases than any of the other compounds. ST 638 is a potent and specific inhibitor of tyrosine kinases in vitro, and that its inhibitory activity is caused by competing with the substrate protein for the tyrosine kinase binding site.
References1. Cancer Res., 1989, 49(9), 2374-2378.
2. Biosci. Biotech. Biochem., 1997, 61(7), 1138-1141.
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4-Hydroxycinnamamide
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