4-Hydroxy-Teriflunomide

Catalogue number C243802
Chemical name4-Hydroxy-Teriflunomide
CAS Number1058722-45-4
Synonyms(2Z)-2-Cyano-3,4-dihydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Molecular WeightC12H8F3N2O3
Formula286.21
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications4-Hydroxy-Teriflunomide is a metabolite of Leflunomide (L322750), an immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutically as a antirheumatic (Merck Index).
ReferencesVrenken, T., et al.: J. Hepatol., 49, 799 (2008), Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008), Davies, M., et al.: J. Med. Chem., 52, 2683 (2009),
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4-Hydroxy-Teriflunomide
Price(USD)
SizePrice(USD)Discount
2.5mg$150.0010% OFF
25mg$1200.0010% OFF
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