3,4-Dihydroxybenzaldehyde

Catalogue number C107996
Chemical name3,4-Dihydroxybenzaldehyde
CAS Number139-85-5
SynonymsProtocatechualdehyde; Protocatechuic aldehyde; Rancinamycin IV; 3,4-Dihydroxybenzyl aldehyde.
Molecular WeightC7H6O3
Formula138.1
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsElectrocatalysis of NADH Oxidation with Electropolymerized Films of 3,4-Dihydroxybenzaldehyde.
3,4-dihydroxybenzaldehyde was found to scavenge DPPH radical, hydroxyl radical and intracellular ROS. Also it chelated Fe2+. In in vitro oxidative DNA damage assay and the expression level of phospho-H2A.X, it inhibited oxidative DNA damage and its treatment decreased the expression level of phospho-H2A.X. And in oxidative cell death and apoptosis assay via MTT assay and Hoechst 33342 staining, respectively, the treatment of 3,4-dihydroxybenzaldehyde attenuated H2O2-induced cell death and apoptosis. These results suggest that the barley may exert the inhibitory effect on H2O2-induced tumor development by blocking H2O2-induced oxidative DNA damage, cell death and apoptosis.
References1. Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 955C; 958C; 959A; 959B; 976A.
2. Anal. Chem., 1994, 66(23), 4337-4344.
3. Anal. Chem., 1997, 69(19), 4065-4075.
4. Phytomedicine, 2009, 16(1), 85-94.
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3,4-Dihydroxybenzaldehyde
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