Catalogue number | C108389 |
Chemical name | 3,4,5-Trimethoxycinnamic acid |
CAS Number | 90-50-6 |
Synonyms | 3-(3,4,5-Trimethoxyphenyl)-2-propenoic acid |
Molecular Weight | C12H14O5 |
Formula | 238.2 |
Purity | 98% |
Physical Description | White cryst. |
Solvent | Chloroform, Dichloromethane,DMSO |
Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
Applications | Anti-stress Effects. Oral administration of 3,4,5-Trimethoxycinnamic acid (TMCA) prolongs sleeping time induced by hexobarbital in mice to exhibit sedative action. We investigate the effects of TMCA on the stress induced with repeated cold exposure or intracerebroventricular injection of corticotrophin-releasing hormone (CRH). Both types of stress significantly reduced the sleeping time induced with pentobarbital in rat, which was significantly prolonged by intraperitoneal injection of TMCA. The intracerebroventricular injection of CRH significantly augmented the content of norepinephrine (NE) in locus coeruleus (LC) of rats, which was significantly suppressed by the intracerebroventricular injection of TMCA. TMCA would exhibit sedative effects by suppressing NE content in LC. |
References | 1. Indian J. Chem., Sect. B, 1977, 15, 583-584. 2. J. Bacteriol., 1981, 147(2), 471-476. 3. Bio. Pharm. Bull., 2004, 27(8), 1317-1319. |
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