2-Trifluoromethyl-2’-methoxychalcone

Catalogue number C260544
Chemical name2-Trifluoromethyl-2’-methoxychalcone
CAS Number1309371-03-6
Synonyms(2E)-1-(2-Methoxyphenyl)-3-[2-(trifluoromethyl)phenyl]-2-propen-1-one;
Molecular WeightC17H13F3O2
Formula306.28
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications2-Trifluoromethyl-2’-methoxychalcone is a novel chalcone derivative as potent Nrf2 activators in mice and human lung epithelial cells. 2-Trifluoromethyl-2’-methoxychalcone is a potent activator of Nrf2, both, in vitro and in mice. 4 Human bronchial epithelial cells treated with 10 μM 2-trifluoromethyl-2’-methoxychalcone showed a marked increase in the expression of the Nrf2-regulated antioxidant genes, GCLM and NQO1.
ReferencesThimmulappa, R., et al.: Cancer Res., 62, 5196 (2002); Rangasamy, T., et al.: J. Exp. Med., 202, 47 (2005); Surh, Y., et al.: Planta Med., 2008, 74, 1526 (2008); Niture, S., et al.: J. Cell Sci., 2009, 122, 4452 (2009);
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2-Trifluoromethyl-2’-methoxychalcone
Price(USD)
SizePrice(USD)Discount
25mg$140.0010% OFF
250mg$1120.0010% OFF
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