2-Chloro-5-nitro-N-4-phenylbenzamide

Catalogue number C215739
Chemical name2-Chloro-5-nitro-N-4-phenylbenzamide
CAS Number22978-25-2
SynonymsGW9662
Molecular WeightC13H8ClN2O3
Formula276.68
Purity98%
Physical DescriptionWhite to Off-White Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsA cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-a (LXRa), retinoic acid receptor (RAR), retinoid X receptor-a (RXRa) and thyroid receptors a and b (TRa and TRb
ReferencesHuang, J.T., et al.: Nature, 400, 378 (1999), Wilson, T.M., et al.: J. Med. Chem., 43, 527 (2000), Leesnitzer, L.M., et al.: Biochemistry, 41, 6640 (2002)
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2-Chloro-5-nitro-N-4-phenylbenzamide
Price(USD)
SizePrice(USD)Discount
1mg$45.0010% OFF
10mg$60.0010% OFF
50mg$235.0010% OFF
5mg$50.0010% OFF
25mg$140.0010% OFF
100mg$445.0010% OFF
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