2,2-Dimethylthiopropionamide

Catalogue number C261024
Chemical name2,2-Dimethylthiopropionamide
CAS Number630-22-8
Synonyms2,2-Dimethylpropanethioamide; NSC 381432; Neopentanethioamide; Thiopivalamide
Molecular WeightC5H11NS
Formula117.21
Purity98%
Physical DescriptionWhite Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications2,2-Dimethylthiopropionamide is used as a reagent to synthesize Dabrafenib, an inhibitor of BRAF kinase that is used to treat BRAF V600-mutation positive carcinoma. BRAF is a gene that mediates cell growth and is activated by mutations caused by cancer. 2,2-Dimethylthiopropionamide is also used as a reagent to prepare sulfonyl-substituted 4,5-diarylthiazoles, compounds that act as cyclooxygenase-2 inhibitors (anti-inflammatory agents).
ReferencesCarter, J., et al.: Bioorg. Med. Chem. Lett., 9, 1167 (1999); Rheault, T., et al.: ACS Med. Chem. Lett., 4, 358 (2013);
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2,2-Dimethylthiopropionamide
Price(USD)
SizePrice(USD)Discount
1g$50.0010% OFF
10g$175.0010% OFF
5g$95.0010% OFF
25g$375.0010% OFF
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