1,4-O-Didesmethyl rac-Niranthin

Catalogue number C252628
Chemical name1,4-O-Didesmethyl rac-Niranthin
CAS Number81263-83-4
Synonyms(2R,3R)-rel-2-[(3,4-dimethoxyphenyl)methyl]-3-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]-1,4-butanediol; (R*,R*)-2-[(3,4-Dimethoxyphenyl)methyl]-3-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]-1,4-butanediol; (R*,R*)-(±)-2-[(3,4-Dimethoxyphenyl)methyl]-3-
Molecular WeightC22H28O7
Formula404.45
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications1,4-O-Didesmethyl rac-Niranthin is an intermediate in the synthesis of rac-Niranthin (N481000), a lignan compound isolated from the plant Phyllanthus amarus and shows anti-leishmanial activity. It acts through induction of topoisomerase I-mediated DNA-protein adduct formation in Leishmania cells triggering apoptosis of cellular nucleases. It also maintains the ability to reduce uric acid concentrations through xanthine oxidase inhibition.
ReferencesSchneiders, G. et al.: Org. Prep. Proc. Int., 14, 1 (1982); Chowdhury, S. et al.: EMBO Mol. Med., 4, 1126 (2012); Murugaiyah, V. et al.: J. Ethnopharm., 124, 233 (2009);
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1,4-O-Didesmethyl rac-Niranthin
Price(USD)
SizePrice(USD)Discount
5mg$175.0010% OFF
50mg$1400.0010% OFF
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