1-(1-iodoethyl)-4-octylbenzene

Catalogue number C244220
Chemical name1-(1-iodoethyl)-4-octylbenzene
CAS NumberN/A
SynonymsFingolimod Impurity 10
Molecular WeightC16H25I
Formula344.27
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications1-(1-iodoethyl)-4-octylbenzene is an impurity of Fingloimod (F805000), also known as FTY720. FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively).
ReferencesBrinkmann, V., et al.: Transplantation, 72, 764 (2001); Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002); Mtaloubian, M., et al.: Nature, 427, 355 (2004)
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1-(1-iodoethyl)-4-octylbenzene
Price(USD)
SizePrice(USD)Discount
15mg$50.0010% OFF
75mg$225.0010% OFF
30mg$95.0010% OFF
150mg$425.0010% OFF
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