Catalogue number | C244220 |
Chemical name | 1-(1-iodoethyl)-4-octylbenzene |
CAS Number | N/A |
Synonyms | Fingolimod Impurity 10 |
Molecular Weight | C16H25I |
Formula | 344.27 |
Purity | 98% |
Physical Description | Powder |
Solvent | Chloroform, Dichloromethane,DMSO |
Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
Applications | 1-(1-iodoethyl)-4-octylbenzene is an impurity of Fingloimod (F805000), also known as FTY720. FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analogue of Sphingosine. FTY720 is a novel immune modulator that prolongs allograft transplant survival in numberour models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 us reported to be phosphorylated by sphingosine kinase to FTY720-P, which has been shown to potently stimulate GTPgS binding activity in S1P-transfected CHO cells (EC50 = 210 pM, 4.9 nM, 4.3 nM, and 1 nM for S1P1, S1P3, S1P4 and S1P5, respectively). |
References | Brinkmann, V., et al.: Transplantation, 72, 764 (2001); Brinkmann, et al.: J. Biol. Chem., 277, 24, 21453 (2002); Mtaloubian, M., et al.: Nature, 427, 355 (2004) |
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After Receiving
The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Sent to your order to our email: info@coompo.com
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