(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline

Catalogue number C253186
Chemical name(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
CAS Number180272-45-1
Synonyms(1R)-1,2,3,4-Tetrahydro-1-phenylisoquinoline; (R)-1,2,3,4-Tetrahydro-1-phenylisoquinoline; (-)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline; (1R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline; (1R)-Phenyl-1,2,3,4-tetrahydroisoquinoline
Molecular WeightC15H15N
Formula209.29
Purity98%
Physical DescriptionOff-White to Pale Beige Solid
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the counterpart to (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline, the latter enantiomer being a key intermediate in the preparation of Solifenacin (S676700), an antimuscarinic agent. Since (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is produced as a by-product, it has been suggested that it should be recycled in order to obtain the S enantiomer on a larger scale. (R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is also used as a reagent to prepare quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives, compounds that act as muscarinic receptor antagonists.
ReferencesBolchi, C., et al.: Org. Process Res. Dev., 17, 432 (2013); Naito, R., et al.: J. Med. Chem., 48, 6597 (2005)
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(R)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
Price(USD)
SizePrice(USD)Discount
1g$150.0010% OFF
5 g$650.0010% OFF
25 g$2000.0010% OFF
2 g$275.0010% OFF
10 g$1200.0010% OFF
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