Catalogue number | C108700 |
Chemical name | alpha-Cyperone |
CAS Number | 473-08-5 |
Synonyms | (4aS,7R)-1,4a-dimethyl-7-(1-methylethenyl)-3,4,5,6,7,8-hexahydronaphthalen-2-one |
Molecular Weight | C15H22O |
Formula | 218.3 |
Purity | 98% |
Physical Description | Cryst. |
Solvent | Chloroform, Dichloromethane,DMSO |
Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
Applications | α-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced expression of inducible COX-2 at both the mRNA and the protein levels. In contrast, α-cyperone had little effect on NO production and iNOS expression. Additionally, α-cyperone downregulated the production and mRNA expression of the inflammatory cytokine IL-6. Moreover, treatment with α-cyperone suppressed the transcriptional activity of NFκB and the nuclear translocation of the p65 NFκB subunit in LPS-induced RAW 264.7 cells. |
References | 1. J. Org. Chem., 1974, 39(17), 2654-2656. 2. J. Org. Chem., 1980, 45(15), 3088-3096. 3. http://www.sciencedirect.com/science/article/pii/S037887411300144X |
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After Receiving
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Sent to your order to our email: info@coompo.com
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