| Catalogue number |
C107897 |
| Chemical name | Xanthotoxin |
| CAS Number | 298-81-7 |
| Synonyms | 9-methoxy-7-furo[3,2-g][1]benzopyranone |
| Molecular Weight | C12H8O4 |
| Formula | 216.2 |
| Purity | 98% |
| Physical Description | Powder |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Synergism between myristicin and xanthotoxin, a naturally cooccurring plant toxicant.
When added to the diet of final instar larvae, xanthotoxin can induce the cytochrome P450 monooxygenase (P450) activity in midgut microsomes by which it is detoxified. Induction is dose-dependent, increasing sevenfold when larvae feed on parsley treated topically with xanthotoxin at 0.5 or 1.0% fresh weight. Although xanthotoxin exerts much of its toxic effects when photoactivated by ultraviolet light, induction of P450 activity did not differ in the presence or absence of ultraviolet light. Despite a 4.7-fold induction of xanthotoxin-metabolizing P450 activity, total P450 content measured in the same microsomal samples did not increase significantly. These data indicate that multiple forms of P450 exist in the black swallowtail midgut and that they are differentially induced by xanthotoxin.
Imperatorin and xanthotoxin protected the animals against maximal electroshock-induced seizures, whereas bergapten and oxypeucedanin, despite their chemical and structural similarities to xanthotoxin and imperatorin, exerted no anticonvulsant activity in this seizure test.
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| References | 1. Acta Cryst., (1972), B28, 2485-2489.
2. Pharmacological Reports, 2010, 62, 1231-1236.
3. Journal of Chemical Ecology, 1985, 11(10), 1349-1358.
4. Journal of Chemical Ecology, 1989, 15(9), 2347-2355.
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| Size | Price(USD) | Discount |
| 5mg | Inquiry | N/A |
| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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