Catalogue number C262547
Chemical nameWYE-687
CAS Number1062161-90-3
SynonymsMethyl 4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d] pyrimidin-6-yl)phenylcarbamate Acid;
Molecular WeightC28H32N8O3
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsWYE-687 is an ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR). Studies have shown the combination of Ras-Raf-MEK1/2 inhibitors with WYE-687 may overcome resistance to mTorKIs thus may be an effective additive therapy for treatment of patient with renal cell carcinoma or colorectal cancer.
ReferencesHuang, Shile., et al.: Cell Cycle, 11, 844 (2012); Yu, K., et al.: Cell Rsch., 15, 6232 (2009);
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