| Catalogue number |
C108622 |
| Chemical name | Tetrandrine |
| CAS Number | 518-34-3 |
| Synonyms | 6,6’,7,12-Tetramethoxy-2,2’-dimethyl-1-beta-berbaman |
| Molecular Weight | C38H42N2O6 |
| Formula | 622.7 |
| Purity | 98% |
| Physical Description | Cryst. |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Tetrandrine has anti-inflammatory, immunologic and antiallergenic effects. It inhibits the degranulation of mast cells. It has a "Quinidine like" anti-arrhythmic effect. It has vasodilatory properties and can therefore reduce blood pressure. Tetrandrine has potential therapeutic value to prevent excess scarring / fibrosis in conjunctiva following trabeculectomy or in patients with severe conjunctival inflammation. Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis.
Tetrandrine may have potential use for the treatment of liver disease and liver cancer. and it also has anti-tumor/growth activities. However, the signaling pathways of tetrandrine-induced growth arrest and apoptosis in cancer cells remain unclear. We investigated the molecular mechanisms of tetrandrine-induced apoptosis and growth arrest in human lung carcinoma cells. Upon treatment with tetrandrine, a time-dependent inhibition of cell growth was observed and cells developed many of the hallmark features of apoptosis. Flow cytometry analysis confirmed that tetrandrine increased populations of both apoptotic sub-G1 and G1 phase. Tetrandrine-induced growth inhibition was associated with induction of Cdk inhibitor p21, inhibition of cyclin D1 and activation of caspase-3. Tetrandrine also affected the expression patterns of cytoskeletons including distribution of F-actin and expression level of microtubule. These results suggest that tetrandrine merits further investigation as a cell cycle blocker as well as a cancer chemopreventive agent.
Tetrandrine presents antiallergic effects, inhibitory effects on pulmonary vessels and airway smooth muscle contraction, and platelet aggregation via its nonspecific calcium channel antagonism that suggested its potential in the treatment of asthma, pulmonary hypertension and chronic obstructive pulmonary disease (COPD). In general, the clinical results to date with tetrandrine in asthma and pulmonary hypertension have been exciting.
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| References | 1. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2004, 60(8-9), 1825-1830.
2. J. Org. Chem., 1976, 41(15), 2548-2551.
3. Journal of Ethnopharmacology, 2000, 69(2), 173-179.
4. Int J Oncol., 2002, 21(6), 1239-1244.
5. Acta Pharmacol Sin., 2002, 23 (1-2), 1107 -1113.
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The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
| Size | Price(USD) | Discount |
| 5mg | Inquiry | N/A |
| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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