Solamargine

Catalogue number C108002
Chemical nameSolamargine
CAS Number20311-51-7
SynonymsSolamargin; Delta-Solanigrine; (3beta,22alpha,25R)-spirosol-5-en-3-yl-O-6-deoxy-alpha-L-mannopyranosyl-(1->2)-O-[6-deoxy-alpha-L-mannopyranosyl-(1->4)]-beta-D-glucopyranoside
Molecular WeightC45H73NO15
Formula868.1
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Solamargine possessed a potent cytotoxicity to human hepatocyte (Hep3B) and normal skin fibroblast. The inhibition curves of solamargine to the both cells were essentially overlapped, suggesting a parallel effect for the cell death. To define mechanism of cytotoxicity of solamargine, the changes of morphology and DNA content in cells were studied. A sub-G1 cell stage was drastically increased after 3-h incubation with solamargine. The results evidence that solamargine arises cell death by apoptosis. In addition, the gene expression of TNFR I were up-regulated within 30 min of solamargine treatment. Since TNF Receptor I has been involved in apoptosis, the overexpression of TNF receptor I may be related with the mechanism of cytotoxicity of solamargine. This communication is the first report that a component of Chinese herbs triggers gene expression of human TNFR I which may lead to cell apoptosis.


SM (solamargine) triggered apoptosis of breast cancer cells (MCF-7 and SK-BR-3 cells) and non-cancerous breast epithelial cells (HBL-100 cells) within 3 h. To extend the application of trastuzumab in breast cancer patients, the regulation of HER2/neu expression by SM was investigated. SM significantly up-regulates HER2/neu expression in breast cancer cells with low and high expression levels of HER2/neu, and synergistically enhanced the effect of trastuzumab in inhibiting cell proliferation. Additionally, HER2/neu and TOP2A [TopoII (topoisomerase II) alpha] genes share the same amplicon on an identical chromosome. Notably, SM co-regulates HER2/neu and TopoIIalpha expression markedly, and enhances TopoII inhibitor-EPI (epirubicin)-induced cytotoxicity to breast cancer cells.


Solamargine could modulate the expressions of TNFRs and Bcl-2, and might be a potential anticancer agent for TNFs and Bcl-2 related resistance of human lung cancer cells.


Solamargine display antifungical, schistosomicidal, antiprotozoal, molluscicidal, antiviral, antimutagenic, and antineoplasic activities against a variety of neoplastic cell lines, as well as hypoglycemic and gastric emptying inhibitory activities.

References

1. Journal of Separation Science, 2009, 32(18), 3126-3132.
2. Bioorganic & Medicinal Chemistry Letters, 2011, 21(10), 2930-2933.
3. Phytochemistry, 1996, 41(6), 1633-1635.
4. FEBS Letters, 2004, 577(1) , 67-74.
5. Biochem. Biophys. Res. Commun., 1996, 229(1), 1-5.
6. Biosci. Rep., 2009, 29(1), 35-45.
7. J. Pharm. Biomed. Anal., 2011, 55(5), 1157-1162.

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Solamargine
Price(USD)
SizePrice(USD)Discount
20mg$205.005% OFF
50mg$472.008% OFF
100mg$802.0015% OFF
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