Rosmarinic acid

Catalogue number C108610
Chemical nameRosmarinic acid
CAS Number20283-92-5
Synonyms(2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)-1-oxoprop-2-enoxy]propanoic acid; Ros A; [[3-(3,4-Dihydroxyphenyl)-1-oxo-2E-propenyl]oxy]-3,4-dihydroxy- benzenepropanoic acid.
Molecular WeightC18H16O8
Formula360.3
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Rosmarinic acid is a natural phenol antioxidant carboxylic acid. The antioxidant activity of rosmarinic acid is stronger than that of vitamin E. Rosmarinic acid helps to prevent cell damage caused by free radicals, thereby reducing the risk for cancer and atherosclerosis.
Rosmarinic acid has a number of interesting biological activities, e.g. antiviral, antibacterial, antiinflammatory and antioxidant. It is also a potential anxiolytic as it acts as a GABA transaminase inhibitor. The presence of rosmarinic acid in medicinal plants, herbs and spices has beneficial and health promoting effects. In plants, rosmarinic acid is supposed to act as a preformed constitutively accumulated defense compound. Rosmarinic acid is used to treat peptic ulcers, arthritis, cataract, cancer, rheumatoid arthritis and bronchial asthma.


Rosmarinic acid has anti-inflammatory properties. A study by Sanbongi C. and colleagues have shown that the oral administration of rosmarinic acid is an effective intervention for allergic asthma. Another study by Youn J. and colleagues demonstrated that rosmarinic acid suppressed synovitis in mice and that it may be beneficial for the treatment of rheumatoid arthritis. Unlike antihistamines, rosmarinic acid prevents the activation of immune responder cells, which cause swelling and fluid formation.


Rosmarinic acid is also used for food preservation. In Japan the perilla extracts, rich in rosmarinic acid, is used the garnish and improve the shelf life of fresh seafood.

References1. Maike Petersena, Monique S.J Simmonds, Phytochemistry, 2003, 62 (2), 121-125.
2. Yinrong Lu, L.Yeap Foo, Phytochemistry, 1999, 51(1), 91-94.
3. Takahiro Nakazawa and Keisuke Ohsawa, J. Nat. Prod., 1998, 61(8), 993-996.
4. Lourdes R. Simpol, et al., Phytochemistry, 1994, 36(1), 91-95.
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Rosmarinic acid
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