Platycodin D

Catalogue number C108416
Chemical namePlatycodin D
CAS Number58479-68-8
Synonyms(4aR,5R,6aR,6aS,6bR,8aR,10R,11S,12aR,14bS)-5,11-dihydroxy-9,9-bis(hydroxymethyl)-2,2,6a,6b,12a-pentamethyl-10-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Molecular WeightC57H92O28
Formula1225.3
Purity98%
Physical DescriptionWhite powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Platycodin D suppressed prostaglandin E2 production at 10 and 30 μM in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoylphorbol 13-acetate (TPA). Western blot analysis revealed that the induction of COX-2 protein by TPA was inhibited by platycodin D in parallel with the inhibition of prostaglandin E2 production. Platycodin D showed no direct effect on COX-1 and COX-2 activities. TPA-induced release of [3H]arachidonic acid from pre-labeled macrophages was also not inhibited by platycodin D.


Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA.
Platycodin D and D3 increased mucin release from rat and hamster tracheal surface epithelial cell culture and also from intact rat trachea upon nebulization. The effect of platycodin D3 was stronger than that of ATP, a potent mucin secretagogue and also of ambroxole, a mucolytic drug. The results from the present study suggest that platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases.

References1. Tetrahedron Letters, 1981, 22(16), 1529-1532.
2. Chemical & Pharmaceutical Bulletin, 1975, 23(11), 2965-2972.
3. Planta Med., 2001, 67(4), 362-364.
4. International Immunopharmacology, 2004, 4(8), 1039-1049.
5. Planta Med., 2002, 68(3), 221-225.
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Platycodin D
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