| Catalogue number |
C103919 |
| Chemical name | Pinosylvin |
| CAS Number | 22139-77-1 |
| Synonyms | |
| Molecular Weight | C14H12O2 |
| Formula | 212.3 |
| Purity | 98% |
| Physical Description | Powder |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Antibacterial agent. Shows fungistatic props.
When bovine aortic endothelial cells (BAECs) were treated with pinosylvin, etoposide- or starvation-induced apoptosis was shown to be significantly reduced. The anti-apoptotic effect of pinosylvin was mediated by inhibition of caspase-3. Moreover, pinosylvin was shown to activate endothelial nitric oxide synthetase (eNOS). At 1 pM, pinosylvin appeared to have a cell-proliferative effect in the endothelial cell. The pinosylvin-induced cell proliferation was declined by treatment with L-NAME, an eNOS inhibitor. Then, we found that pinosylvin had a stimulatory effect on cell migration and tube formation. These stimulatory effects suggest that pinosylvin is likely to act as a pro-angiogenic factor. Yet another effect of pinosylvin was inhibition of lipopolysaccharide-induced THP-1 cell adhesion to endothelial cells. Altogether, we propose that pinosylvin may be utilized as a phytotherapic agent for the prevention of cardiovascular inflammatory diseases.
The antibacterial and antifungal activities of pinosylvin, a constituent of pine, were studied and compared with those of resveratrol. Pinosylvin exhibited more potent growth inhibitory activity against Candida albicans and Saccharomyces cerevisiae.
Pinosylvin significantly inhibited LPS-induced NF-κB activation in a concentration- dependent manner. Additionally, pinosylvin was found to inhibit the LPS-induced phosphorylation and degradation of IκB α in THP-1 cells. Therefore, we have attempted to determine whether pinosylvin can inhibit the expression of cytokines possessing NF-κB binding sites in their promoter regions. In a consistent result, pinosylvin inhibited LPS-induced production of TNF α and interleukin-8 (IL-8).
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| References | 1. Tetrahedron, 1986, 42, 2725.
2. Phytother Res., 2013, 27(4), 610-617.
3. Fitoterapia, 2005, 76(2), 258-260.
4. Neuro Endocrinol Lett., 2008, 29(5), 802-805.
5. Planta Med., 2006, 72(9), 801-806.
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The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
| Size | Price(USD) | Discount |
| 5mg | Inquiry | N/A |
| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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