O2-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate

Catalogue number C262310
Chemical nameO2-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate
CAS Number179344-98-0
Synonyms1-(Ethenyloxy)-3-(2-pyrrolidinyl)-3-(5-pyrrolidinyl)-1-triazenamine 2-oxide; 1-[(Ethenyloxy)-NNO-azoxy]-pyrrolidine; V-PYRRO/NO;
Molecular WeightC6H11N3O2
Physical DescriptionPale Yellow Oil
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsV-PYRRO/NO is a metabolically activated nitric oxide (NO) donor drug that can be used to selectively target NO delivery to the liver. The compound is metabolized by the liver, and spontaneously decomposes with a half-life of 3 seconds, liberating NO. Infusion of 30nmol/kg of V-PYRRO/NO in rats causes only a slight drop in blood pressure. At concentrations >100ug, V-PYRRO/NO increases hepatocyte viability against TNF-a-induced apoptosis by approximately 2-fold compared to cells not treated with this compound. UV/Vis: lmax: 267nm e: 9,700
ReferencesSaavedra, J., et al.: J. Med. Chem., 40, 1947 (1997), Liu, J., et al.: J. Pharmacol. Exp. Ther., 310, 18 (2004), Lluch, P., et al.: J. Hepatol., 41, 55 (2004), Liu, J., et al.: Toxicology, 208, 289 (2005),
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O2-Vinyl 1-(Pyrrolidin-1-yl)diazen-1-ium-1,2-diolate
50mg$125.0010% OFF
250mg$450.0010% OFF
100mg$225.0010% OFF
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