Neobavaisoflavone

Catalogue number C104687
Chemical nameNeobavaisoflavone
CAS Number41060-15-5
Synonyms4’,7-Dihydroxy-3’-(3-methyl-2-butenyl)isoflavone; 7-Hydroxy-3-[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-4H-1-benzopyran-4-one
Molecular WeightC20H18O4
Formula322.4
Purity98%
Physical DescriptionCryst.
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Neobavaisoflavone was isolated as a DNA polymerase inhibitor.


In the present study we investigated in vitrothe anti-inflammatory activity of neobavaisoflavone. Macrophages play an important role in inflammation through the release of inflammatory mediators involved in the immune response. Inappropriate and prolonged macrophage activation is largely responsible for the pathology of acute and chronic inflammatory conditions. Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40, IL-12p70, TNF-α in LPS+IFN-γ– or PMA– stimulated RAW264.7 macrophages.


Neobavaisoflavone concentration-dependently promoted osteogenesis in MC3T3-E1cells, demonstrated by notable enhancement of alkaline phosphatase (ALP) activity, increase of bone-specific matrix proteins expression including type I collagen (Col-I), osteocalcin (OCN) and bone sialoprotein (BSP), and formation of bone nodules. Neobavaisoflavone up-regulated the expression of runt-related transcription factor 2 (Runx2) and Osterix (Osx), the bone-specific transcription factors participating in regulation of bone marker genes expression. the osteogenic activity of neobavaisoflavone might probably act through activation of p38-dependent signaling pathway to up-regulate the mRNA levels of Runx2 and Osx then stimulate bone matrix proteins expression. Neobavaisoflavone might be a potential anabolic agent to treat bone loss-associated diseases.

References1. Bull. Chem. Soc. Japan, 1978, 51(8), 2398-2400.
2. Journal of Chromatography B, 2005, 821(1), 67-74.
3. J. Nat. Prod. , 1998, 61(3), 362-366.
4. Molecules, 2011, 16(5), 3701-3712.
5. Phytomedicine, 2012, 19(6), 551-561.
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Neobavaisoflavone
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