| Catalogue number |
C108795 |
| Chemical name | L-Carnitine inner salt |
| CAS Number | 541-15-1 |
| Synonyms | (3R)-3-hydroxy-4-(trimethylammonio)butanoate; Levocarnitine; 3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium inner salt Carnitine, Carnitor, L-Carnitine |
| Molecular Weight | C7H15NO3 |
| Formula | 161.2 |
| Purity | 98% |
| Physical Description | Powder |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Facilitator of long-chain fatty acids through mitochondrial membranes, thus allowing their metabolic oxidn. Regulator of blood lipid levels, used in sport and infant nutrition. Drug used to increase cardiac output and improve myocardial function; often administered after haemodialysis. Used to treat primary carnitine deficiency.
The beneficial effects of L-carnitine administration were studied in vivo in isolated perfused working hearts from control and diabetic rats. Control and streptozocin-induced diabetic (STZ-D) rats were treated daily for 6 wk with high-dose L-carnitine (3 g•kg−1•day−1 i.p.). STZ-D results in loss of body weight and hypoinsulinemia. These effects were not altered by L-carnitine treatment. Myocardial free-carnitine levels were decreased in the untreated diabetic rats. L-Carnitine treatment of the diabetic rats increased myocardial free-carnitine levels, which were comparable with those of control rats. Six weeks after STZ administration, hearts from untreated diabetic animals exhibited depressed left ventricular developed pressure, cardiac contractility, and ventricular relaxation rates compared with control animals. However, this depression was not seen in the L-carnitine-treated diabetic animals. L-Carnitine treatment of diabetic rats significantly reduced plasma glucose and lipid levels but had no effect on control rats. Furthermore, thyroid hormone levels were higher in the L-carnitine-treated diabetic rats than in the untreated diabetic group. The data suggest that high-dose L-carnitine treatment may reduce the severity of diabetes and result in improved cardiac performance.
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| References | 1. Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 1, 1227A; 1276C
2. Diabetes, 1988, 37(10), 1358-1364.
3. Trends Biochem. Sci., 1977, 2, 207
4. European Journal of Clinical Pharmacology, 1989, 37(1), 59-63.
5. The Journal of Nutritional Biochemistry, 1998, 9(10), 575-581.
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The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
| Size | Price(USD) | Discount |
| 5mg | Inquiry | N/A |
| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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