KU-0058948

Catalogue number C240888
Chemical nameKU-0058948
CAS Number763111-49-5
Synonyms4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone; KU 0058948; KU0058948; 1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine;
Molecular WeightC21H21FN4O2
Formula380.42
Purity98%
Physical DescriptionPale Yellow to Yellowish Beige
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsKU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 is a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro
ReferencesKlevernic, I.V. et al.: FEBS Lett., 583, 680 (2009); Gaymes, T.J. et al.: Haematologica, 94, 638 (2009);
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KU-0058948
Price(USD)
SizePrice(USD)Discount
2.5mg$140.0010% OFF
100mg$1975.0010% OFF
10mg$225.0010% OFF
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