Isotanshinone IIA

Catalogue number C108025
Chemical nameIsotanshinone IIA
CAS Number20958-15-0
Synonymsiso-Tanshinone II; 1,2,3,4-Tetrahydro-4,4,8-trimethylphenanthro[3,2-b]furan-7,11-dione
Molecular WeightC19H18O3
Formula294.4
Purity98%
Physical DescriptionRed powder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsProtein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. Bioassay-guided fractionation and purification afforded three related abietane-type diterpene metabolites 1-3. Compounds 1-3 were identified as isotanshinone IIA (1), dihydroisotanshinone I (2), and isocryptotanshinone (3) mainly by analysis of NMR and MS data. Compounds 1-3 non-competitively inhibited PTP1B activity with 50% inhibitory concentration values of 11.4+/-0.6 uM, 22.4+/-0.6 uM and 56.1+/-6.3 uM, respectively.
References1. Journal of Pharmaceutical and Biomedical Analysis, 2005, 38(3), 564-570.
2. Biological and Pharmaceutical Bulletin, 2005, 28(9), 1795-1797.
3. Molecules, 2012, 17, 10470-10493.
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Isotanshinone IIA
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