Catalogue number C107854
Chemical nameIsoacteoside
CAS Number61303-13-7
Synonyms[(2R,3R,4S,5R,6R)-5-(3,4-Dihydroxyphenyl)-6-ethoxy-3,5-dihydroxy-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
Molecular WeightC29H36O15
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze

Isoverbascoside, a phenylethanoid glycoside, was isolated from Chinese folk medicine herb Pedicularis striata Pall. Isoverbascoside possess the activity of inducing differentiation in SMMC-7721 cells. Isoverbascoside is capable of inducing differentiation in human hepatocellular carcinoma (HCC) cell line SMMC-7721. When treated with isoverbascoside, the proliferation of SMMC-7721 cells was markedly inhibited in a dose- and time-dependent manner, and the average cell population doubling time was delayed.

Isoverbascoside inhibited cell proliferation, reversed cell malignant phenotypic characteristics, and consequently caused differentiation in MGC 803 cells. These effects might be associated with its activities of causing G_0/G_1 arrest and regulating the expression of cell cycle related proteins.
Isoverbascoside as possible food antioxidant.

References1. Chem. Pharm. Bull., 1982, 30, 2732-2737.
2. Chem. Pharm. Bull., 1987, 35, 3309-3314.
3. Planta Medica, 2002, 68(4), 370-372.
4. Acta Pharmacologica Sinica, 2002, 23(11), 997-1001.
5. J. Agric. Food Chem., 2012, 60(7), 1822-1829.
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