HZ-52

Catalogue number C242112
Chemical nameHZ-52
CAS Number1077626-51-7
Synonyms2-[[4-([1,1’-biphenyl]-4-ylamino)-6-chloro-2-pyrimidinyl]thio]octanoic Acid; HZ 52;
Molecular WeightC24H26ClN3O2S
Formula456
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
ApplicationsA potent, reversible inhibitor of 5-lipoxygenase, blocking leukotriene synthesis with an IC50 value of 0.7 μM in intact human polymorphonuclear leukocytes. It also attenuates leukotriene B4 synthesis, prevents carrageenan-induced pleurisy, and protects against platelet-activating factor-induced shock in mice when given intraperitoneally.
ReferencesGreiner, C. et al.: Br. J. Pharmacol., 164, 781 (2011); Koeberle, A. et al.: J. Med. Chem., 51, 8068 (2008);
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HZ-52
Price(USD)
SizePrice(USD)Discount
10mg$150.0010% OFF
100mg$1200.0010% OFF
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