Glycyrrhizic acid

Catalogue number C108567
Chemical nameGlycyrrhizic acid
CAS Number1405-86-3
Synonyms(2S,3S,4S,5R,6R)-6-[[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxy-3-oxanyl]oxy]-3,4,5-trihydroxy-2-oxan
Molecular WeightC42H62O16
Formula822.9
Purity98%
Physical DescriptionPowder
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

Glycyrrhizie acid is active against viruses. It inhibits growth and cytopathology of several unrelated DNA and RNA viruses, while not affecting cell activity and ability to replicate. In addition, glycyrrhizic acid inactivates herpes simplex virus particles irreversibly.


Glycyrrhizie acid was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro. Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index.

References1. J. Med. Chem., 2005, 48(4), 1256-1259.
2. J. Phys. Chem. B, 2005, 109(51), 24526-24530.
3. J. Phys. Chem. B, 2008, 112(14), 4435-4440.
4. Nature, 1979, 281(5733), 689-690.
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Glycyrrhizic acid
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