Catalogue number C108755
Chemical nameGastrodin
CAS Number62499-27-8
Synonyms(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[4-(hydroxymethyl)phenoxy]oxane-3,4,5-triol Gastrodine;4-(beta-D-glucopyranosyloxy) benzyl alcohol
Molecular WeightC13H18O7
Physical DescriptionWhite cryst.
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze

Phenolic glucoside gastrodin (Gas), which is a main component extracted from the Chinese herbs Gastrodia elata Bl, is a well-known natural calcium antagonist with antioxidant and anti-inflammatory functions. It has long been used clinically for treatment of cardiovascular and cerebrovascular diseases. Previous studies have shown that gastrodin possesses comprehensive pharmacological functions. However, very little is known about whether gastrodin has protective role on cardiac hypertrophy. The aim of this study was to determine whether gastrodin attenuates pressure overload-induced cardiac hypertrophy in mice and to clarify the underlying molecular mechanisms. Our data demonstrated that gastrodin prevented cardiac hypertrophy induced by aortic banding (AB), as assessed by heart weight/body weight and lung weight/body weight ratios, echocardiographic parameters, and gene expression of hypertrophic markers. The inhibitory effect of gastrodin on cardiac hypertrophy is mediated by ERK1/2 signaling and GATA-4 activation. Further studies showed that gastrodin attenuated fibrosis and collagen synthesis through abrogating ERK1/2 signaling pathway. Therefore, these findings indicated that gastrodin, which is a potentially safe and inexpensive therapy for clinical use, has protective potential in targeting cardiac hypertrophy and fibrosis through suppression of ERK1/2 signaling.

Gastrodin significantly attenuate levels of neurotoxic proinflammatory mediators and proinflammatory cytokines by inhibition of the NF-κB signaling pathway and phosphorylation of MAPKs in LPS-stimulated microglial cells. Arising from the above, we suggest that gastrodin has a potential as an anti-inflammatory drug candidate in neurodegenerative diseases.

Gastrodin is an effective and a safe drug for the prevention of neurocognitive decline in patients undergoing mitral valve replacement surgery with CPB.

References1. Chinese Journal of Biotechnology, 2006, 22(5), 800-805.
2. Archives of Pharmacal Research, 1999, 22(2), 219-224.
3. Mol. Cell Biochem., 2012, 359(1-2), 9-16.
4. PLoS One., 2011, 6(7), e21891.
  Fill your Email(  
After Receiving
The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
Featured Products
C108536Isochlorogenic acid C$166.00/20mg
C101411Ganoderol B$294.00/5mg
Orders by E-mail
Orders can be placed by Emails. All orders received will be shipped in the next day if the stock is available.

To place an order, please provide the following information.

1) Your name and telephone number
2) Purchase order number
3) Product number, package size, description, and quantity
4) Shipping and billing addresses

Sent to your order to our email:
Discount Request
If you have any questions about discounts or dealer discount, please send us a message. We will be glad to help.
Go directly to Coompo product type beginning with
  • Contact Us

  • Email:
  • Tel: +86-27-84396673
  • Building B, No.77 Chuangye Rd,
  • Wuhan Economic and Technological Development Zone,
  • Hubei 430056, PRC
  • ©2013-2017 Coompo  |  All rights reserved.