Catalogue number C108006
Chemical nameEupatilin
CAS Number22368-21-4
Molecular WeightC18H16O7
Physical DescriptionYellow cryst.
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze

Eupatilin has been known to possess anti-peptic, anti-oxidate, anti-cancer, and anti-allergy activity. The synthetic derivate of eupatilin is called DA-6034.Eupatilin acts as a novel antioxidant and may play an important role in DA-9601-mediated effective repair of the gastric mucosa.

Eupatinil suppresses inflammatory responses by the inhibition of NF-kappaB signaling pathway. As such, many different types of human tumors have misregulated NF-kappaB: that is, NF-kappaB is constitutively active. Active NF-kappaB turns on the expression of genes that keep the cell proliferating and protect the cell from conditions that would otherwise cause it to die via apoptosis.

The topical anti-inflammatory activity of eupatilin was investigated using the inhibition of the Croton-oil-induced dermatitis in the mouse ear as the end point. eupatilin is endowed with potent in vivo topical anti-inflammatory activity, qualitatively similar to that of hydrocortisone and intermediate in terms of potency between those of steroid and non-steroid drugs.

References1. Turk. J. Chem., 2009, 33, 813-823.
2. Pharm. Res., 2008, 25(6),1355-1364.
3. J. Agric. Food Chem., 2009, 57(17), 7726-7730.
4. Korean J. Physiol Pharmacol., 1997, 1(5), 573-580.
5. Food Chemistry, 2011, 129(2), 679-683.
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