Catalogue number |
C107906 |
Chemical name | Cryptotanshinone |
CAS Number | 35825-57-1 |
Synonyms | (1R)-1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[1,2-g]benzofuran-10,11-dione |
Molecular Weight | C19H20O3 |
Formula | 296.4 |
Purity | 98% |
Physical Description | Powder |
Solvent | Chloroform, Dichloromethane,DMSO |
Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
Applications | Cryptotanshinone could have diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity. This property might offer an opportunity to study underlying mechanisms for the different antitumor effects of administered Cryptotanshinone in B16 and B16BL6 cells.
Cryptotanshinone, the major active constituent isolated from the root of Salvia miltiorrhiza Bunge, has been recently evaluated for its anti-cancer activity, but the molecular mechanisms underlying these activities remain poorly understood. In particular, it remains completely unknown as to whether or not cryptotanshinone can induce endoplasmic reticulum (ER) stress. Herein, we identify cryptotanshinone as a potent stimulator of ER stress, leading to apoptosis in many cancer cell lines, including HepG2 hepatoma and MCF7 breast carcinoma, and also demonstrate that mitogen-activated protein kinases function as mediators in this process. Reactive oxygen species generated by cryptotanshinone have been shown to play a critical role in ER stress-induced apoptosis. Cryptotanshinone also evidenced sensitizing effects to a broad range of anti-cancer agents including Fas/Apo-1, TNF-α, cisplatin, etoposide or 5-FU through inducing ER stress, highlighting the therapeutic potential in the treatment of human hepatoma and breast cancer.
Displays antibacterial and anti-inflammatory activity and acts as an antidiabetes and antiobesity agent via activation of AMP-activated protein kinase (AMPK). Also improves cognitive impairment in Alzheimer's disease transgenic mice by inhibition of acetylcholinesterase (IC50 = 4.09 μM) and reduction in Aβ peptide generation.
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References | 1. Phytochemistry, 1983, 22(3), 721-722. 2. Phytochemistry, 1989, 28(11), 3233-3234. 3. Archives of Pharmacal Research, 2005, 28(8), 909-913. 4. Journal of Asian Natural Products Research, 2009, 11(6), 482-489. 5. Cancer Chemother Pharmacol., 2011, 68(1), 17-27. 6. Apoptosis, 2012, 17(3), 248-257. 7. Cancer research, 2009, 69(1), 193-202.
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Size | Price(USD) | Discount |
5mg | Inquiry | N/A |
10mg | Inquiry | N/A |
25mg | Inquiry | N/A |
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