Beta-Asarone

Catalogue number C101190
Chemical nameBeta-Asarone
CAS Number5273-86-9
Synonyms1,2,4-Trimethoxy-5-(1-propenyl)benzene; 1,2,4-trimethoxy-5-(1Z)-1-propenylbenzene; (Z)-1,2,4-Trimethoxy-5-propenylbenzene; (Z)-Asarone; (Z)-Azarone; cis-Asarone; cis-Isoasarone
Molecular WeightC12H16O3
Formula208.3
Purity98%
Physical DescriptionOil
SolventChloroform, Dichloromethane,DMSO
StorageStored at 2-8°C, Protected from air and light, refrigerate or freeze
Applications

β-Asarone can affect the central nervous system. β-Asarone could attenuate neuronal apoptosis in rat hippocampus and might be a potential candidate for development as a therapeutic agent to manage cognitive impairment associated with conditions such as Alzheimer’s disease. Other authors found β-Asarone could reduce the toxicity of excitatory amino acids and increase the expression of c-fos in the epileptic rat brain. In addition, β-Asarone could reduce the injuries of blood vessel endothelium and nerve cells of the cortex and improve the cognitive function of the beta-amyloid hippocampus injection rats.


Complement β-Asarone is protective against cerebral ischemia in specific way. The administration of β-Asarone could reduce focal cerebral ischemic/reperfusion injury. The Mechanism of β-Asarone in protection of cerebral ischemia was via increasing antioxidants activity related to lesion pathogenesis.

References1. Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 2, 209C; 210A .
2. BMC Complementary and Alternative Medicine 2013, 13, 236.
3. Life Sci., 1998, 5, 591-599.
4. Biol. Pharm. Bull., 2010, 5, 836-843.
5. J. Med. Plants Res., 2011, 5, 1728-1734.
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Beta-Asarone
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