| Catalogue number |
C108740 |
| Chemical name | Arctigenin |
| CAS Number | 7770-78-7 |
| Synonyms | (3R,4R)-4-[(3,4-dimethoxyphenyl)methyl]-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2-oxolanone |
| Molecular Weight | C21H24O6 |
| Formula | 372.4 |
| Purity | 98% |
| Physical Description | Powder |
| Solvent | Chloroform, Dichloromethane,DMSO |
| Storage | Stored at 2-8°C, Protected from air and light, refrigerate or freeze |
| Applications | Arctigenin is the aglycone of arctiin. It has shown antiviral and anticancer effects.
Here it was found to activate AMP-activated protein kinase (AMPK), and the mechanism by which this occurred, as well as the effects on glucose and lipid metabolism were investigated. A new role for arctigenin as a potent indirect activator of AMPK via inhibition of respiratory complex I, with beneficial effects on metabolic disorders in ob/ob mice. This highlights the potential value of arctigenin as a possible treatment of type 2 diabetes. arctigenin might be used as a potential lead compound for the discovery of the agents with mimic exercise training effects to treat metabolic diseases.
Arctigenin selectively promoted glucose-starved A549 tumor cells to undergo necrosis by inhibiting mitochondrial respiration. arctigenin elevated cellular level of reactive oxygen species (ROS) and blocked cellular energy metabolism in the glucose-starved tumor cells. combined arctigenin with the glucose analogue 2-deoxyglucose (2DG) and examined their effects on tumor cell growth. The combination of arctigenin and 2DG may represent a promising new cancer therapy with minimal normal tissue toxicity.
Arctigenin inhibited T lymphocyte proliferation and decreased the gene expression of IL-2, IFN-γ and NF-AT.
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| References | 1. J. Med. Chem., 1996, 39(1), 86-95.
2. Phytochemistry, 1982, 21(7), 1824-1825.
3. Fitoterapia, 1999, 70(2), 212-213.
4. Biochemical Pharmacology, 2012, 84(4), 468-476.
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The packaging of the product may have turned upside down during transportation, resulting in the product adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
| Size | Price(USD) | Discount |
| 5mg | Inquiry | N/A |
| 10mg | Inquiry | N/A |
| 25mg | Inquiry | N/A |
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